To defend against Zika, we need fast evolution in a slow world
EVOLOCITY
Zika Defense

3D Representation of the Zika Virus
3-D representation of the Zika virus courtesy of Manuel Almagro Rivas
If you were a child living in Central Africa, you wouldn’t pay any attention to Zika virus. In Uganda, in Nigeria, in the Central African Republic, where the virus has been lurking for decades or centuries, you’d get bitten by a mosquito when you were running through a field or playing among the trees. You’d have come down with a low fever and a little rash. Or you’d have felt nothing at all — and that would be that. When you got pregnant, years later, you’d never fear that your child might be born with a small head and tragically-damaged brain, because that wasn’t anything you’d ever seen. You, and all your friends, wouldn’t be susceptible to Zika virus infection while you were pregnant because, very likely, you’d already be immune.

That, as John Brooks of the Centers for Disease Control and Prevention in Atlanta, Georgia, argues, is the natural history of Zika virus — a relatively benign infection, apparently originating in monkeys, which didn’t cause much trouble as it moved around into people. If, on occasion, a pregnant woman had a microcephalic child because she’d escaped infection earlier, that was a tragic event, and no one associated it with a mosquito bite in a place where mosquito bites were endless.

But, Brooks explains, when the virus moved into Brazil, spreading among people who’d never been infected with it before, that hideous side effect erupted. It’s not that the virus became more deadly, it’s that it played grotesque havoc in a virgin population. The world froze. What would happen when athletes from around the world converged in Rio for the Olympic Games? Where would the virus go, and how would it evolve? Were we prepared for a pandemic of Zika virus, which not infrequently produces, among pregnant woman, such a dreadful, irremediable condition as microcephaly?

Then things got even more frightening. It wasn’t just mosquitoes that spread the virus: people spread it too, via sexual transmission. It seems, says Brooks, that Zika virus, like Ebola virus, can apparently reproduce floridly in the male testes, a protected environment that the immune system does not penetrate. It’s expressed in semen and spreads through male-female and male-male contact. It’s also been found in vaginal secretions, and in one documented case, a woman passed the infection to her male partner.

Making things still more worrisome, only 20% of people infected with Zika show any symptoms at all. That means that 80% of infected people could be silently spreading the disease through mosquitos or through sex. Zika has appeared in several districts in Miami and elsewhere in the United States, and the numbers are increasing. With the threat of silent spread, are we looking at the evolution of a new, sexually-transmitted disease like AIDS?

But Zika isn’t going to take over the United States or much of the Western world any time soon. As Stephen Morse of the Mailman School of Public Health at Columbia University points out, the Zika virus shares the inherent limitations of all mosquito-borne infections when they run up against our infrastructure, our screens and air-conditioning: mosquitoes can’t get through. They can’t infect enough people to maintain the disease. West Nile virus, which has caused 20,265 neuroinvasive (brain-affecting) cases and 1783 deaths in the US since its introduction in 1999, is, in some ways, more of a threat than Zika because it lives in the blood of certain common birds, blue jays and crows among them. Zika doesn’t have any natural hosts besides primates and humans. So it has to rely on infected humans as its hosts, and those hosts, in the air-conditioned West, are hard to get to.

CDC map of Zika
CDC map of Zika worldwide, 2016
But not impossible. Local transmission has appeared already, in the Wynnwood district of Miami and elsewhere. That trendy neighborhood has its rougher patches, where some houses are unscreened. Areas of the country — parts of Texas, the Gulf Coast, the Mississippi Delta — have plenty of homes with no screens or air-conditioning. As evolutionary biologist Paul W. Ewald of the University of Louisville points out, small pockets of dengue fever, spread by the same mosquito that spreads Zika, pop up in those regions periodically. We can expect to see pockets of Zika as well.

Also, the mosquitos that spread Zika and dengue are day-biters — they can attack you while you’re working in your garden or walking to the car. But that doesn’t change the risk profile too much, says Ewald: “If you’re sick, you stay indoors, where if you’ve got screens you won’t get bitten.” That makes it harder for mosquitos to get infected in the first place, and greatly reduces the chances of spread, as we see with dengue.

As for Zika evolving into an efficient sexually-transmitted germ, that too is unlikely. Brooks points out that all the data now available indicate that the presence of live Zika virus in semen drops off sharply after 40 days or so. Viral RNA can be detected in semen for many months, but that doesn’t mean a man could infect his partner with live virus. The CDC, cautions Brooks, advises any man infected with Zika virus to avoid unprotected sex for at least 60 days after recovery. And women, says Ewald, are likely a dead-end in most cases, because there doesn’t seem to be any evidence that the virus reproduces in vaginal tissues. The message is obvious: infected men need to use condoms, and couples living in areas with heavy transmission should likely use condoms throughout the course of a pregnancy.

For mosquito-borne transmission, the message is clear too, though it’s probably not something that people want to hear. Many people would first think of vaccination. Vaccines, however, must first be developed and shown to be safe and effective — a long, onerous, expensive process, which works for one germ at a time. And in some cases, dengue and malaria for instance, no one has ever been able to develop a safe, reliable vaccine at all. But building up infrastructure throughout the nation would reduce the threat of all mosquito-borne diseases to almost nothing. “I would like to see a federal program that is designed to make all houses in the United States mosquito-proof,” says Ewald. “Throughout the Southern states, Texas to Florida — the government should set up screens and/or air-conditioning."

And it’s been done before: the Tennessee Valley Authority screened houses (each for less than the cost of a case of malaria) and essentially eliminated malaria from the United States. The same thing happened after World War II in Italy.

What about the rest of the world? Screens on every hut and hovel? Well, yes. Dr. Andrew Haddow of the United States Army Medical Research Institute of Infectious Diseases describes essentially screening the world as the passion of his life. Haddow, whose grandfather was the co-discoverer of the Zika virus back in 1947, realized on a visit to Africa that bed nets are badly employed by many people, who toss them off as too hot or turn them into fishing nets. He points out that screens, combined with tiny solar-power units to be used to air-condition huts or supply them with fans, might go a long way to minimizing the threat of all mosquito-borne agents- malaria, yellow fever, dengue, chikungunya, Rift Valley Fever, mosquito-borne encephalitis, West Nile virus as well as Zika. Malaria alone kills millions: we are dependent now on drenching huts with DDT, passing out bed nets with all their liabilities, and treating the sick with less and less effective drugs as the malaria parasites develop resistance. Malaria vaccines consistently defeat our best efforts, and no current vaccines are available for most of the other diseases.

But screens are effective not just against one or two pathogens but all. Haddow plans to apply for a pilot project to test his “screens and air-circulation” idea in one village in Africa, to show how his proposed method would work. Screens block some air circulation, leaving tropical huts hotter than ever, but adding some air-conditioning, or even just electric fans, would go a long way towards replicating the safety of Western infrastructure.

And there’s another, evolutionary reason to try out Haddow’s method, and to switch to screens and air-conditioning as primary prevention. According to Ewald, by largely preventing seriously-ill people from being bitten, you’d be reducing the virulence of the disease, thus forcing the Zika microbe to evolve. Imagine that the sickest people are lying supine on their beds, too weak to swat away foraging mosquitos. Now think what sort of strains those deathly-ill patients would likely be harboring. If bugs couldn’t bite the sickest people, and were forced to dine only on the blood of those healthy enough to be walking around outside, the strains those mosquitos would transmit would be likely much less virulent ones. Those people harboring the most virulent disease would be out of the reach of mosquitoes: they’d be hidden away behind their screens, unbitten. So malaria and other mosquito-borne diseases would be passing around parasites from the blood of those less seriously infected. This, according to Ewald, would force the evolution of milder strains of malaria and other mosquito-borne diseases, a double benefit for the screening protocol.

Screens are passive protection — you don’t have to think about them. You do have to maintain them, but that’s a secondary problem. First, let’s get them installed. It would require a lot of money and a lot of will. But you could essentially eliminate the threat and burden of lethal mosquito-borne diseases from the entire planet.

Think about it.


This article copyright © 2016 by Alpha Cygni, Inc. and Wendy Orent. All rights reserved.